Adjective
1. irritating
4. maddening
5. trying
6. tiresome
7. troublesome
8. bothersome
9. nettlesome
10. obnoxious
11. irksome
12. vexing
13. cursed
14. vexatious
15. galling
16. aggravating
17. pesky
Noun
18. annoyance
19. irritation
20. vexation
Verb
21. irritate
22. vex
24. anger
25. exasperate
26. irk
27. gall
28. pique
30. antagonize
31. get on someone's nerves
32. get to
35. nettle
36. rub the wrong way
37. aggravate
38. peeve
39. hassle
40. miff
41. rile
42. needle
43. frost
44. bug
45. get someone's goat
46. get someone's back up
47. get in someone's hair
48. give someone the gears
50. drive around the bend
51. drive up the wall
52. tee off
53. tick off
55. rankle